O-PHOSPHO-D-SERINE
- Product Name
- O-PHOSPHO-D-SERINE
- CAS No.
- 73913-63-0
- Chemical Name
- O-PHOSPHO-D-SERINE
- Synonyms
- D-SOP;D-Ser(H2PO3)-OH;H-D-SER(H2PO3)-OH;H-D-SER(PO3H2)-OH;D-SERINE(PO3H2)-OH;O-PHOSPHO-D-SERINE;D-Serine-O-phosphate;O-Phospho-D-serine≥ 99% (TLC);o-phospho-d-serinecrystalline;(2R)-2-amino-3-phosphonooxypropanoic acid
- CBNumber
- CB1282740
- Molecular Formula
- C3H8NO6P
- Formula Weight
- 185.07
- MOL File
- 73913-63-0.mol
O-PHOSPHO-D-SERINE Property
- storage temp.
- -15°C
- solubility
- insoluble in DMSO; insoluble in EtOH; ≥18.5 mg/mL in H2O with gentle warming and ultrasonic
N-Bromosuccinimide Price
- Product number
- 17602
- Product name
- O-Phospho-D-Serine
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $106
- Updated
- 2022/04/27
- Product number
- 17602
- Product name
- O-Phospho-D-Serine
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $202
- Updated
- 2022/04/27
- Product number
- P353725
- Product name
- O-Phospho-D-serine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 287775
- Product name
- O-Phospho-D-serine
- Packaging
- 250mg
- Price
- $382
- Updated
- 2021/12/16
- Product number
- C5331
- Product name
- O-Phospho-D-Serine
- Packaging
- 250mg
- Price
- $106
- Updated
- 2021/12/16
O-PHOSPHO-D-SERINE Chemical Properties,Usage,Production
Chemical Properties
White powder
Definition
ChEBI: O-phospho-D-serine is the D-enantiomer of O-phosphoserine. It is a conjugate acid of an O-phosphonatooxy-D-serine(2-). It is an enantiomer of an O-phospho-L-serine.
Biological Activity
o-phospho-d-serine is a weak agonist of the metabotropic glutamate receptor mglur4.mglur4 receptors, a member of the g protein-linked family of receptors for glutamate, are negatively coupled to camp. its expression is highest in granule cells of the cerebellum that send parallel fibers that synapse with purkinje cell dendrites.
in vitro
the affinity of l-serine-o-phosphate was examined in a baby hamster kidney cells expressing subtype mglur1 or mglur4 of the mglur family. results showed that both l-serine-o-phosphate or o-phospho-d-serine at 3 mm did not inhibit pi-hydrolysis as stimulated by 10 μm glutamate in bhk cells expressing mglur1. however, l-serine-o-phosphate was a potent agonist at the mglur4 subtype, which was negatively coupled to adenylate cyclase, while o-phospho-d-serine was found to be weakly active [1]. in another study, to test whether phosphatidylserine was recognized by amebae, calcium-treated cells were incubated with annexin v prior to adherence to or ingestion by e. histolytica. it was found that the coreceptor could be inhibited by phospho-l-serine and to a lesser extent by o-phospho-d-serine but not by phospho-l-threonine, which was consistent with the coreceptor functioning in the adherence and ingestion of erythrocytes via recognition of phosphatidylserine [2].
IC 50
1,260 μm for the metabotropic glutamate receptor mglur4
References
[1] thomsen, c. , and suzdak, p.d. serine-o-phosphate has affinity for type iv, but not type i, metabotropic glutamate receptor. neuroreport 4, 1099-1101 (1993).
[2] boettner, d. r.,huston, c.d.,sullivan, j.a., et al. entamoeba histolytica and entamoeba dispar utilize externalized phosphatidylserine for recognition and phagocytosis of erythrocytes. infection and immunity 73(6), 3422-3430 (2005).
O-PHOSPHO-D-SERINE Preparation Products And Raw materials
Raw materials
Preparation Products
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