2-FLUORO-3-IODOBENZOIC ACID Chemical Properties

Boiling point:

331.0±27.0 °C(Predicted)

Density 

2.074±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.92±0.10(Predicted)

form 

crystalline powder

color 

Faint brown

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HS Code 

2916399090

2-FLUORO-3-IODOBENZOIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-fluoro-3-iodobenzoic acid from 2-fluoro-3-iodobenzonitrile: A mixture of 2-fluoro-3-iodobenzonitrile (5.00 g, 20.2 mmol), dioxane (16 mL), and concentrated sulfuric acid (25 mL) was heated to 115 °C and reacted for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble material. Water was added to the filtrate and the aqueous phase was extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-fluoro-3-iodobenzoic acid (4.42 g, 82% yield) as a white solid. Mass spectrum (LRMS) m/z: 265 ([M-H]-). 1H-NMR (CDCl3) δ: 6.94-7.01 (m, 1H), 7.90-7.97 (m, 2H).

References

[1] Patent: EP2113503, 2009, A1. Location in patent: Page/Page column 32
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 21, p. 6253 - 6257

2-FLUORO-3-IODOBENZOIC ACID(447464-03-1)Related Product Information

• 3-Iodobenzoic acid
• 3-HYDROXY-2,4,6-TRIIODOBENZOIC ACID