Neurogenic locus notch homolog protein 2 precursor Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Neurogenic locus notch homolog protein 2 precursor Usage And Synthesis

Uses

research pathology

General Description

Anti-NOTCH2 (Cleaved-Val¹⁶⁹⁷) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Val¹⁶⁹⁷) protein.

Biochem/physiol Actions

The NOTCH2 gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.

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