(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL Chemical Properties

Boiling point:

403.4±47.0 °C(Predicted)

Density 

1.268±0.06 g/cm3(Predicted)

pka

8.31±0.10(Predicted)

InChI

InChI=1S/C9H9N5/c10-5-7-1-3-8(4-2-7)9-13-11-6-12-14-9/h1-4,6H,5,10H2

InChIKey

JGCOJRPYFRRONJ-UHFFFAOYSA-N

SMILES

C1(CN)=CC=C(C2=NN=CN=N2)C=C1

(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL Usage And Synthesis

Uses

Tetrazine-Amine is a tetrazine linker that can be used to covalently label live cells through a cycloaddition[1][2]. Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

References

[1] Devaraj NK, et, al. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6. DOI:10.1002/anie.200903233
[2] Devaraj NK, et, al. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec;19(12):2297-9. DOI:10.1021/bc8004446

(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine HCL(1092689-33-2)Related Product Information

• PTH-EPSILON-PHENYLTHIOCARBAMYL-DL-LYSINE
• Tetrazine-NHS Ester