2-Chloro-6-methoxypurine Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

HS Code 

2933998090

2-Chloro-6-methoxypurine Usage And Synthesis

Synthesis

To a solution of 2,6-dichloro-9H-purine (1 g, 5.29 mmol) in methanol (15 mL) was added a methanolic solution of 25% sodium methanolate (1.26 mL, 5.89 mmol). The reaction mixture was heated to 80 °C and kept for 1 h, followed by cooling to room temperature. The resulting precipitate was collected by filtration, washed with ice-cold methanol and dried to afford 2-chloro-6-methoxypurine 920 mg (94% yield) as a white solid. Mass spectrometry analysis showed m/z 185.36 [M + 1].

References

[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[2] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 123
[3] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6019 - 6021
[4] Molecules, 2011, vol. 16, # 7, p. 5840 - 5860

2-Chloro-6-methoxypurine(1198-46-5)Related Product Information

• 2-Chloro-6-methoxypyridine
• 2-CHLORO-6-METHOXYPYRAZINE