2-CHLORO-6-METHOXYPYRAZINE Chemical Properties

Boiling point:

183.3±35.0 °C(Predicted)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

-1.79±0.10(Predicted)

Appearance

Off-white to light yellow Solid-liquid mixture

Safety Information

Risk Statements 

41

Safety Statements 

26-39

HS Code 

2933998090

2-CHLORO-6-METHOXYPYRAZINE Usage And Synthesis

Synthesis

1. Methanol (MeOH, 0.27 mL, 6.7 mmol) was dissolved in 15 mL of tetrahydrofuran (THF). 2. Add sodium hydride (NaH, 60 wt% mineral oil dispersion, 0.32 g, 8.0 mmol) to the above solution and stir for 30 minutes at room temperature. 3. 2,6-dichloropyrazine (1.0 g, 6.7 mmol) dissolved in 20 mL of THF was added slowly and stirring was continued for 16 hours at room temperature. 4. Upon completion of the reaction, the reaction was quenched by the addition of aqueous ammonium chloride and the reaction mixture was extracted with ether (Et2O). 5. The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and purified by column chromatography to afford the target product, 2-chloro-6-methoxypiperazine (0.71 g, 73% yield). 6. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 8.14 (1H, s), 8.13 (1H, s), 3.99 (3H, s).

References

[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0467

2-CHLORO-6-METHOXYPYRAZINE(33332-30-8)Related Product Information

• 2-Chloro-6-methoxypurine
• 2-Chloro-6-methoxypyridine
• 2-CHLORO-6-METHOXYPYRAZINE
• 2-(BENZYLOXY)-6-CHLOROPYRAZINE
• 2-CHLORO-3-METHOXYPYRAZINE
• 2-Chloropyrazine
• 2-CHLORO-6-PHENOXY PYRAZINE
• 2-chloro-6-(cyclohexyloxy)pyrazine
• 2-chloro-6-ethoxypyrazine
• 2-chloro-6-(2-ethoxyethoxy)pyrazine
• 2-CHLORO-6-(2-HYDROXYETHOXY) PYRAZINE
• 2-chloro-6-isopropoxypyrazine
• 2-chloro-6-(2,2,2-trifluoroethoxy)pyrazine
• METHYL 3-AMINO-6-CHLORO-5-METHOXYPYRAZINE-2-CARBOXYLATE
• 2-Chloro-5-methoxypyrazine
• 3-CHLORO-5-METHOXYPYRAZINE-2-CARBALDEHYDE
• METHYL 6-CHLORO-3-METHOXYPYRAZINE-2-CARBOXYLATE
• 5-CHLORO-3-METHOXYPYRAZINE-2-CARBALDEHYDE