Bromoacetamido-PEG2-Acid Chemical Properties

Boiling point:

491.4±45.0 °C(Predicted)

Density 

1.464±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

4.28±0.10(Predicted)

form 

Solid-Liquid Mixture

color 

White to yellow

Bromoacetamido-PEG2-Acid Usage And Synthesis

Description

Bromoacetamido-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromoacetamido-PEG2-Acid(1415800-44-0)Related Product Information

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• Bromoacetamido-PEG4-NHS ester