(S)-tert-butyl 2-((1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2-ylamino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Chemical Properties

Boiling point:

527.8±50.0 °C(Predicted)

Density 

1.099±0.06 g/cm3(Predicted)

pka

13.66±0.20(Predicted)

form 

Solid

color 

White to off-white

(S)-tert-butyl 2-((1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2-ylamino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate Usage And Synthesis

Uses

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162)[1].

References

[1] Xiao Chao, et al. Monomethyl auristatin E single crystal as standard or reference substance and preparation method thereof. China, CN116768966 A. 2023-09-19.

(S)-tert-butyl 2-((1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2-ylamino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate(160800-82-8)Related Product Information

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