Acebilustat
Acebilustat Basic information
- Product Name:
- Acebilustat
- Synonyms:
-
- ZK 322
- ZK 322;ZK-322
- ZK-322
- CS-2501
- Acebilustat(ZK322)
- Acebilustat
- CTX-4430
- Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-
- CAS:
- 943764-99-6
- MF:
- C29H27N3O4
- MW:
- 481.54
- Mol File:
- 943764-99-6.mol
Acebilustat Chemical Properties
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
- form
- A crystalline solid
- CAS DataBase Reference
- 943764-99-6
Acebilustat Usage And Synthesis
Description
Acebilustat (also known as CTX-4430) is a new once-daily oral anti-inflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of leukotriene A4 hydrolase, which is responsible for the production of leukotriene B4 (LTB4). The later is a molecule that leads to inflammation. Therefore, Acebilustat can treat inflammation through suppressing the production of leukotriene B4.
References
https://www.cff.org/Trials/Pipeline/details/108/CTX-4430
Springman, E., et al. "127 Pharmacokinetic and pharmacodynamic profile of CTX-4430 in two phase 1 studies." Journal of Cystic Fibrosis14(2015):S90-S90.
Springman, E., et al. "126 A phase 1 clinical study of CTX-4430 in cystic fibrosis patients." Journal of Cystic Fibrosis 14(2015):S90-S90.
Elborn, J. S., et al. "Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction." Clinical & Translational Science 10.1(2017):20-27.
AcebilustatSupplier
- Tel
- 19182167371 19182167371
- service@synlord.com
- Tel
- sales@boylechem.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 021-52996696，15000506266 15000506266
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com