THEOPHYLLOL
THEOPHYLLOL Basic information
- Product Name:
- THEOPHYLLOL
- Synonyms:
-
- THEOPHYLLINE SODIUM ACETATE
- THEOPHYLLOL
- aceticacid,sodiumsalt,compd.withtheophylline(1:1)
- 7-Theophyllineacetic acid sodium salt
- aceticacid,sodiumsalt,mixt.with3,7-dihydro-1,3-dimethyl-1h-purine-2,6-d
- acet-theocinsodium
- ionesodiumsalt
- theocinsoluble
- CAS:
- 8002-89-9
- MF:
- C9H14N4Na2O4
- MW:
- 288.21
- Mol File:
- 8002-89-9.mol
THEOPHYLLOL Chemical Properties
- form
- powder to crystal
- color
- White to Almost white
- CAS DataBase Reference
- 8002-89-9
THEOPHYLLOL Usage And Synthesis
Uses
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
in vivo
Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO[1].
| Animal Model: | Male Swiss mice[1] |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneal injection; daily, for 9 days |
| Result: | Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
IC 50
IL-10; IL-6; PDE3; Human Endogenous Metabolite
References
[1] Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. PMID:7664866
[2] Chung IY, et, al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000 Aug 1;203(2):95-102. DOI:10.1006/cimm.2000.1678
[3] Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):558-61. DOI:10.1007/s00210-001-0494-x
[4] Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. DOI:10.1073/pnas.132556899
[5] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. DOI:10.1164/rccm.201302-0388PP
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