N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Basic information
- Product Name:
- N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
- Synonyms:
-
- N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
- N-EPSILON-ACETIMIDOYL-L-LYSINE
- N-EPSILON-ACETIMIDOYL-L-LYSIN-EPSILON
- H-LYS(1-IMINOETHYL)-OH
- H-LYS(ACETIMIDOYL)-OH
- LYSINE(ACETIMIDOYL)-OH
- N-(5-Amino-5-carboxypentyl
- Ne-Acetimidoyl-L-lysine
- CAS:
- 53774-63-3
- MF:
- C8H17N3O2
- MW:
- 187.24
- Mol File:
- 53774-63-3.mol
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N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Chemical Properties
- Boiling point:
- 335.2±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- Water: 50 mg/mL (267.04 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
- pka
- 2.52±0.24(Predicted)
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N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Usage And Synthesis
Biological Activity
L-NIL is an inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 value of 3.3 μM for miNOS.
in vitro
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that it is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L -NMA or L-NNA.
target
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)
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