CPI-444
CPI-444 Basic information
- Product Name:
- CPI-444
- Synonyms:
-
- 1-(2-fluorobenzyl)-4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
- A2A receptor antagonist 1
- A2AR antagonist 1
- 1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(2-fluorophenyl)methyl]-4-(2-furanyl)-
- CPI444,CPI 444,Adenosine Receptor,disease,Parkinson,Inhibitor,CPI-444,hypolocomotion,inhibit,model,P1 receptor
- CPI-444 analog
- A2A receptor antagonist 1, 10 mM in DMSO
- CAS:
- 443103-97-7
- MF:
- C16H12FN5O
- MW:
- 309.3
- Mol File:
- 443103-97-7.mol
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CPI-444 Chemical Properties
- Boiling point:
- 570.6±60.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 62 mg/mL (200.45 mM)
- form
- Solid
- pka
- 3.17±0.10(Predicted)
- color
- White to off-white
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CPI-444 Usage And Synthesis
Uses
A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively[1].
References
[1] Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DOI:10.1016/j.bmcl.2008.03.072
CPI-444Supplier
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