Val-Ala-PAB Chemical Properties

Melting point:

65-68°C

Boiling point:

584.9±50.0 °C(Predicted)

Density 

1.191±0.06 g/cm3(Predicted)

storage temp. 

-20°C, Inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

13.51±0.70(Predicted)

form 

Solid

color 

White to Off-White

Val-Ala-PAB Usage And Synthesis

Description

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.