AZD-1390
AZD-1390 Basic information
- Product Name:
- AZD-1390
- Synonyms:
-
- CS-2816
- 7-Fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-2H-imidazo[4,5-c]quinolin-2-one
- AZD-1390;AZD 1390
- AZD-1390
- 2H-Imidazo[4,5-c]quinolin-2-one, 7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-
- 7-fluoro-1-isopropyl-3-methyl-8-(6-(3-(piperidin-1-yl)propoxy)pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
- azd1390,ATM/ATR,azd-1390,ATM and RAD3 related,AZD 1390,inhibit,Inhibitor,Ataxia telangiectasia mutated
- 7-fluoro-1-isopropyl-3-methyl-8-(6-(3-(piperidin-1-yl)propoxy)pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one
- CAS:
- 2089288-03-7
- MF:
- C27H32FN5O2
- MW:
- 477.57
- Mol File:
- 2089288-03-7.mol
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AZD-1390 Chemical Properties
- Boiling point:
- 617.4±55.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:10.0(Max Conc. mg/mL);20.93(Max Conc. mM)
Ethanol:80.0(Max Conc. mg/mL);168.51(Max Conc. mM) - form
- A solid
- pka
- 9.22±0.10(Predicted)
- color
- White to off-white
- InChIKey
- VQSZIPCGAGVRRP-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(C3=CC=C(OCCCN4CCCCC4)N=C3)=C(F)C=2)C2N(C(C)C)C(=O)N(C)C=2C=1
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AZD-1390 Usage And Synthesis
Uses
AZD 1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor.
in vivo
Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390[2].
IC 50
ATM
AZD-1390Supplier
Hangzhou ChangCun Biotechnology Co., Ltd. Gold
- Tel
- 0571-; 13567100326
- 158848739@qq.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
ChemStrong Scientific Co.,Ltd
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com