Recilisib sodium
Recilisib sodium Basic information
- Product Name:
- Recilisib sodium
- Synonyms:
-
- Ex-Rad
- 4-[(E)-2-[(4-chlorophenyl)methylsulfonyl]ethenyl]benzoate
- 4-I(E)-2-[(4-chlorophenyl)methanesulfonyl] ethenyl]benzoate sodium
- Brand name: Ex-RAD
- ON 01210.Na
- ON01210 sodium
- ON-01210 sodium
- CAS:
- 922139-31-9
- MF:
- C16H12ClNaO4S
- MW:
- 360.78
- Mol File:
- 922139-31-9.mol
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Recilisib sodium Usage And Synthesis
Uses
Recilisib sodium (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells[1].
in vivo
Recilisib sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure[1].
References
[1] Kang AD, et al. ON01210.Na (Ex-RAD) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. DOI:10.1371/journal.pone.0058355
Recilisib sodiumSupplier
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