FK-448 Free base
FK-448 Free base Basic information
- Product Name:
- FK-448 Free base
- Synonyms:
-
- FK-448 Free base
- 1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester
- FK 448 Free base,FK448 Free base
- CAS:
- 85858-76-0
- MF:
- C25H30N2O3
- MW:
- 406.52
- Mol File:
- 85858-76-0.mol
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FK-448 Free base Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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FK-448 Free base Usage And Synthesis
Uses
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM.
in vivo
FK-448 (20 mg/kg, i.p.) results in a decrease in the blood glucose level, and inhibits the degradation of insulin by pancreatic enzymes in rats. FK-448 (20 mg/kg, p.o.) also decreases the blood glucose level, and increases plasma IRI level in dogs[2].
References
[1] Fujii S, et al. New synthetic inhibitors of chymotrypsin. J Biochem. 1984 Feb;95(2):319-22. DOI:10.1093/oxfordjournals.jbchem.a134611
[2] Fujii S, et al. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985 Aug;37(8):545-9. DOI:10.1111/j.2042-7158.1985.tb03064.x
FK-448 Free baseSupplier
Twochem Co.Ltd.
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- 021-58111628 15800915896
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Angel Pharmatech, Ltd.
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TargetMol Chemicals Inc.
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Beijing Jin Ming Biotechnology Co., Ltd.
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