CHLOROACETYL FLUORIDE
CHLOROACETYL FLUORIDE Basic information
- Product Name:
- CHLOROACETYL FLUORIDE
- Synonyms:
-
- CHLOROACETYL FLUORIDE
- Chloroacetyl fluoride 98%
- Chloroacetylfluoride98%
- 2-chloroacetyl fluoride
- Acetyl fluoride, chloro- (6CI,7CI,8CI,9CI)
- CAS:
- 359-14-8
- MF:
- C2H2ClFO
- MW:
- 96.49
- Mol File:
- 359-14-8.mol
CHLOROACETYL FLUORIDE Chemical Properties
- Boiling point:
- 75°C
- Density
- 1.38 g/cm3
Safety Information
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 23-26-36/37/39-45
- RIDADR
- 3265
- Hazard Note
- Corrosive
- HS Code
- 2915907098
CHLOROACETYL FLUORIDE Usage And Synthesis
Uses
Chloroacetyl Fluoride is used as an acylating agent and a precursor to chloroacetylium ion.
Preparation
Chloroacetyl Fluoride is generally prepared by fluorination of ClCH2COCl. A variety of reagents has been employed for this transformation, including benzoyl fluoride/KH2F, KHF2, KF, KF/tetraalkylammonium chloride, and dialkylaminosulfur trifluoride. Preparation of ClCH2COF may also be accomplished from ClCH2CO2H through the use of 2- chloro-1,1,2-trifluoroethyldiethylamine as the fluoride source. Treatment of ClCH2CF2CF2OCH3 with SO3 leads to the formation of ClCH2COF in 94% yield, which is the highest yield reported for the preparation of the reagent.
storage
Chloroacetyl Fluoride is corrosive, moisture sensitive, and should be stored under anhydrous conditions. This reagent should be handled in a fume hood.