CTAP
CTAP Basic information
- Product Name:
- CTAP
- Synonyms:
-
- H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
- D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
- CTAP
- CYS2, TYR3, ARG5, PEN7-AMIDE
- H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7)
- CTAP, ≥95%
- 7)-disulfide
- M.W. 1104.30 C51H69N13O11S2
- CAS:
- 103429-32-9
- MF:
- C51H69N13O11S2
- MW:
- 1104.3
- Product Categories:
-
- Neuropeptides
- Opioid Peptides
- Other Opioid Peptides
- Other Opioid PeptidesPeptides for Cell Biology
- Opioid receptor and opioid-like receptor
- Peptide
- Mol File:
- 103429-32-9.mol
CTAP Chemical Properties
- storage temp.
- -20°C
- form
- Solid
- color
- off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- {d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
MSDS
- Language:English Provider:SigmaAldrich
CTAP Usage And Synthesis
Uses
CTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake.
Uses
CTAP has been used as a μ-opioid receptor (MOR) antagonist:
- to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
- to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats
- to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons
Biochem/physiol Actions
CTAP is a peptide antagonist produced from somatostatin analogs.
in vivo
CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect[1].
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].
| Animal Model: | Male Sprague-Dawley rats[1] |
| Dosage: | 0, 0.1, 0.5, 1 mg/kg |
| Administration: | IP, single |
| Result: | Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg. |
IC 50
μ Opioid Receptor/MOR: 3.5 nM (IC50); δ Opioid Receptor/DOR: 4500 nM (IC50)
storage
Store at -20°C
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