CTOP
CTOP Basic information
- Product Name:
- CTOP
- Synonyms:
-
- threoninamide
- NALTRIBEN
- NTB
- D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR AMIDE
- D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
- DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
- CTOP
- CYS2,TYR3,ORN5,PEN7-AMIDE
- CAS:
- 103429-31-8
- MF:
- C50H67N11O11S2
- MW:
- 1062.26
- Product Categories:
-
- peptide
- Neuropeptides
- Opioid Peptides
- Other Opioid Peptides
- Other Opioid PeptidesPeptides for Cell Biology
- Opioid receptor and opioid-like receptor
- Mol File:
- 103429-31-8.mol
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CTOP Chemical Properties
- Boiling point:
- 1491.2±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- RTECS
- XO8578200
- storage temp.
- -20°C
- pka
- 9.90±0.15(Predicted)
- form
- Powder
- color
- white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- {D-Phe}-Cys-Tyr-{D-Trp}-{Orn}-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
MSDS
- Language:English Provider:SigmaAldrich
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CTOP Usage And Synthesis
Uses
CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
Uses
CTOP has been used:
- to study the anxiogenic effects induced by CTOP in mice and rat.
- to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
- to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
General Description
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
Biochem/physiol Actions
Selective ligand for μ-opioid receptors.
in vivo
CTOP (0-0.5 nmol, ICV, once) antagonizes the analgesic effect of morphine in a dose-dependent manner[1].
CTOP (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in morphine-dependent animals[1].
CTOP (0-1.5 nmol per side, Intra-VTA injection) enhances extracellular dopamine levels in the nucleus accumbens and dose-dependently enhances locomotor activity[2].
| Animal Model: | Male CFLP mice (25-30 g)[1] |
| Dosage: | 0, 0.001, 0.05, 0.075, 0.1, and 0.5 nmol (made up in artificial cerebrospinal fluid (CSF) and kept in plastic tubes at -25℃ until use) |
| Administration: | Intracerebroventricular (i.c.v.) administration, once |
| Result: | Antagonized the analgesic effect of morphine in a dose-dependent manner, antagonized the morphine-induced hypermotility in a dose-dependent manner. |
| Animal Model: | Male CFLP mice (25-30 g, Acute dependence to morphine was induced by a single dependence-inducing (100 mg/kg) dose of morphine-HC1)[1] |
| Dosage: | 0, 0.001, 0.05, 0.2, and 2 nmol |
| Administration: | Intracerebroventricular (i.c.v.) administration, once |
| Result: | Decreased the body temperature in a dose-dependent manner, and caused withdrawal hypothermia and a loss of body weight in morphine-dependent animals. |
| Animal Model: | Long-Evans hooded rats (12, male, 350-450 g)[2] |
| Dosage: | 0, 0.015, 0.15, and 1.5 nmol per side |
| Administration: | Intra-VTA (ventral tegmental area) injection |
| Result: | Enhanced extracellular dopamine levels in the nucleus accumbens, dose-dependently increased activity, whereas had no effect on feeding and drinking behavior. |
IC 50
μ Opioid Receptor/MOR
storage
Store at -20°C
CTOPSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
Cellmano Biotech Limited
- Tel
- 0551-65326643 18156095617
- info@cellmano.com
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CTOP(103429-31-8)Related Product Information
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