CTOP Chemical Properties

Boiling point:

1491.2±65.0 °C(Predicted)

Density 

1.42±0.1 g/cm3(Predicted)

RTECS 

XO8578200

storage temp. 

-20°C

pka

9.90±0.15(Predicted)

form 

Powder

Water Solubility 

Soluble to 1 mg/ml in water

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CTOP Usage And Synthesis

Uses

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.

Uses

CTOP has been used:

• to study the anxiogenic effects induced by CTOP in mice and rat.
• to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
• to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

General Description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Biochem/physiol Actions

Selective ligand for μ-opioid receptors.

storage

Store at -20°C

CTOP(103429-31-8)Related Product Information

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