CMP-NAN SODIUM SALT Chemical Properties

storage temp. 

−20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

color 

White to off-white

biological source

synthetic (organic)

Safety Information

WGK Germany 

3

F 

10-21

MSDS

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CMP-NAN SODIUM SALT Usage And Synthesis

Description

CMP-Sialic acid is a form of the sugar N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5’-monophosphate (CMP). In vertebrates, it is biosynthesized within the nucleus from CTP and Neu5Ac by CMP-sialic acid synthetases. Sialyltransferases transfer Neu5Ac from CMP-sialic acid to various acceptor substrates, most commonly at terminal positions of the oligosaccharide component of glycoproteins or glycolipids. Sialic acid-containing glycans at the cell surface play important roles in cell interactions and have roles in infection, inflammation, and cancer.

Uses

CMP-N-acetylneuraminic acid sodium salt is a nucleotide and CMP-?sialic acid derivative used as a building block used in the preparation of N-?glycan microarrays.

IC 50

Human Endogenous Metabolite

References

[1] ANJA K MüNSTER-KüHNEL. Structure and function of vertebrate CMP-sialic acid synthetases.[J]. Glycobiology, 2004, 14 10: 43R-51R. DOI: 10.1093/glycob/cwh113
[2] TSUJI S. Molecular cloning and functional analysis of sialyltransferases.[J]. Journal of biochemistry, 1996, 120 1: 1-13. DOI: 10.1093/oxfordjournals.jbchem.a021369
[3] MAGALI AUDRY. Current trends in the structure-activity relationships of sialyltransferases.[J]. Glycobiology, 2011, 21 6: 716-726. DOI: 10.1093/glycob/cwq189
[4] HENNET T. From glycosylation disorders back to glycosylation: What have we learned?[J]. Biochimica et biophysica acta. Molecular basis of disease, 2009, 1792 9: Pages 921-924. DOI: 10.1016/j.bbadis.2008.10.006
[5] ANNIE N SAMRAJ. Involvement of a non-human sialic Acid in human cancer.[J]. Frontiers in Oncology, 2014: 33. DOI: 10.3389/fonc.2014.00033

CMP-NAN SODIUM SALT(1007117-62-5)Related Product Information

• N-Acetylneuraminic acid
• CYTIDINE 5'-MONOPHOSPHO-N-