Prasugrel-d5 Chemical Properties

storage temp. 

Store at -20°C

solubility 

Chloroform: slightly soluble,Methanol: slightly soluble

form 

A solid

Prasugrel-d5 Usage And Synthesis

Description

Prasugrel-d₅ is intended for use as an internal standard for the quantification of prasugrel by GC- or LC-MS. Prasugrel is a prodrug form of the platelet purinergic P2Y₁₂ receptor antagonist R-99224. Prasugrel (0.3 and 3 mg/kg) inhibits ex vivo washed platelet aggregation in rat platelet rich-plasma. In vivo, prasugrel prevents thrombus formation (ED₅₀ = 0.68 mg/kg) and increases tail bleeding time in rats. Formulations containing prasugrel have been used in the prevention of blood clots.

Uses

A novel labelled antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome

IC 50

P2Y12 Receptor

References

[1] A. SUGIDACHI. Antiplatelet action of R‐99224, an active metabolite of a novel thienopyridine‐type Gi‐linked P2T antagonist, CS‐747[J]. British Journal of Pharmacology, 2001, 132 1. DOI: 10.1038/sj.bjp.0703761
[2] ATSUHIRO SUGIDACHI. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties[J]. British Journal of Pharmacology, 2009, 129 7: 1439-1446. DOI: 10.1038/sj.bjp.0703237

Prasugrel-d5(1127252-92-9)Related Product Information

• 1-cyclopropyl-2-(2-fluorophenyl)ethane-1,2-dione
• 2-Desacetoxy Prasugrel
• 5-(2-cyclopropyl-1-(4-fluorophenyl) -2-oxoethyl)-4,5,6,7-tetrahydrothieno [3,2-c]pyridin-2-yl acetate
• 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2(3H)-one
• 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
• Mesna Methyl Ester 2-Bromo Analog
• Prasugrel Metabolite M5
• PRASUGREL METABOLITE R-138727
• IZCHRAOWOKMDHU-UHFFFAOYSA-N
• Cyclopropyl 4-Fluorobenzyl Ketone
• 2-BroMo-1-cyclopropyl-2-(3-fluorophenyl)ethanone
• trans-R-138727
• 1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide
• Prasugrel Impurity 26 HCl
• Prasugrel alpha-Hydroxy IMpurity
• Prasugrel IMpurity (1-BroMo-5-chloro-1-(2-fluorophenyl)pentan-2-one)
• 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-7a-hydroxy-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
• 2-BroMo-1-cyclopropyl-2-(4-fluorophenyl)ethanone