trans-Cevimeline Hydrochloride Chemical Properties

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

trans-Cevimeline Hydrochloride Usage And Synthesis

Description

trans-Cevimeline HCl, also known as AF 102A, is the trans-isomer of AF102B (Cevimeline). Cevimeline is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.

Uses

trans-Cevimeline Hydrochloride is a reagent in the preparation of spiro-oxathiolane/quinuclidine sulfoxide derivative for the treatment of central nervous and cholinergic system disease or disorders.

in vivo

trans-Cevimeline Hydrochloride(107220-29-1)Related Product Information

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