ETHYL 3-CHLOROBENZOYLFORMATE Chemical Properties

Boiling point:

88°C 0,1mm

Density 

1.2270 g/cm3

storage temp. 

Sealed in dry,Room Temperature

Appearance

pale yellow liquid

CAS DataBase Reference

62123-73-3(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

ETHYL 3-CHLOROBENZOYLFORMATE Usage And Synthesis

Synthesis

GENERAL METHODS: 3-Chlorobenzoylacetonitrile (1.0 mmol) and PIDA (2.2 mmol) were dissolved in ethanol (8 mL), and the reaction was stirred under reflux conditions for 0.5 hours. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio 20:1 petroleum ether/ethyl acetate) to afford the target product ethyl 3-chlorobenzoylformate. Note: The solvent used in this synthesis step is methanol (MeOH).

References

[1] Tetrahedron Letters, 2015, vol. 56, # 24, p. 3793 - 3795

ETHYL 3-CHLOROBENZOYLFORMATE(62123-73-3)Related Product Information

• ETHYL 2-CHLOROBENZOYLFORMATE
• ETHYL 4-CHLOROBENZOYLFORMATE,Ethyl 4-chlorobenzoylformate Ethyl 2-(2,4-dichlorophenyl)-2-oxoacetate (4-Chlorophenyl)glyoxylic acid ethyl ester
• ETHYL 3,5-DICHLOROBENZOYLFORMATE
• ETHYL 3-CHLORO-4-FLUOROBENZOYLFORMATE
• ETHYL 2,3-DICHLOROBENZOYLFORMATE
• ETHYL 3,4-DICHLOROBENZOYLFORMATE
• ETHYL 3-CHLOROBENZOYLFORMATE
• ETHYL 3-CHLORO-5-FLUOROBENZOYLFORMATE