DL-CATECHIN
DL-CATECHIN Basic information
- Product Name:
- DL-CATECHIN
- Synonyms:
-
- TRANS-1,2,4,5-BENZENETETRACARBOXYLIC ACID
- TRANS-2-(3,4-DIHYDROXYPHENYL)3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL
- TRANS-PYROMELLITIC ACID
- DL-CATECHIN
- DL-CATECHIN CATECHINS
- (-)-CYANIDANOL-3
- CATECHINS
- CATECHIN, DL-
- CAS:
- 88191-48-4
- MF:
- C15H16O7
- MW:
- 308.29
- Mol File:
- 88191-48-4.mol
DL-CATECHIN Chemical Properties
- storage temp.
- 2-8°C
- CAS DataBase Reference
- 88191-48-4(CAS DataBase Reference)
Safety Information
- WGK Germany
- 3
- F
- 10
MSDS
- Language:English Provider:SigmaAldrich
DL-CATECHIN Usage And Synthesis
Uses
Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
Definition
ChEBI: The monohydrate of (+)-catechin.
in vivo
Animals treated with Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)[3].
IC 50
COX-1: 1.4 μM (IC50)
References
[1] Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. DOI:10.1207/S15327914NC402_14
[2] Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167. DOI:10.1186/1756-9966-29-167
[3] Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259. DOI:10.1007/s10616-017-0138-8
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