1R,3S-RSL 3 Chemical Properties

Boiling point:

641.3±55.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

pka

16.09±0.60(Predicted)

1R,3S-RSL 3 Usage And Synthesis

Uses

(1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 μM and 0.004 μM, rspectively[1].

Definition

ChEBI: (1R,3S)-2-(2-chloro-1-oxoethyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylic acid methyl ester is a harmala alkaloid.

References

[1] Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. DOI:10.1016/j.freeradbiomed.2018.01.019