N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Basic information
- Product Name:
- N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
- Synonyms:
-
- N,N-DIMETHYLPHOSPHORAMIC DICHLORIDE
- N,N-DIMETHYLPHOSPHORAMIDIC DICHLORIDE
- N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
- PHOSPHORIC ACID DIMETHYLAMIDE DICHLORIDE
- DIMETHYLAMINOPHOSPHORYL DICHLORIDE
- DIMETHYLAMINE PHOSPHORYL DICHLORIDE
- DIMETHYLAMIDOPHOSPHORIC DICHLORIDE
- DMPADC
- CAS:
- 677-43-0
- MF:
- C2H6Cl2NOP
- MW:
- 161.95
- EINECS:
- 211-641-2
- Mol File:
- 677-43-0.mol
N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Chemical Properties
- Boiling point:
- 77-79 °C/11 mmHg (lit.)
- Density
- 1.362 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.464
- Flash point:
- 89-90°C/20mm
- storage temp.
- 2-8°C
- solubility
- Miscible with dimethoxyethane.
- pka
- -6.60±0.70(Predicted)
- form
- Oil to Semi-Solid
- color
- Colourless to Off-White
- Sensitive
- Moisture Sensitive
- BRN
- 969956
- Stability:
- Hygroscopic, Moisture Sensitive
- CAS DataBase Reference
- 677-43-0
- EPA Substance Registry System
- N,N-Dimethyl phosphoramidic dichloride (677-43-0)
Safety Information
- Hazard Codes
- C
- Risk Statements
- 34-37
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 3265 8/PG 3
- WGK Germany
- 3
- RTECS
- TB4025000
- F
- 1-3-10
- HazardClass
- 8
- PackingGroup
- II
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Usage And Synthesis
Chemical Properties
Light yellow liquid
Uses
N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.
Application
N,N-dimethylphosphoramidodichloridate is an electrophilic phosphorylating reagent used to convert vicinal diols to alkenes and to activate carboxylic acids and alcohols towards nucleophiles.
Preparation
N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE is obtained by treatment of Phosphorus Oxychloride with dimethylamine.
N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE(677-43-0)Related Product Information
- N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE (DIMETHYLAMINOPHOSPHORYL DICHLORIDE; N,N-DIMETHYLPHOSPHORAMIC DICHLORIDE; DMPADC
- N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE (DIMETHYLAMINOPHOSPHORYL DICHLORIDE; N,N-DIMETHY
- DI-CHLORO N,N-DIISOPROPYLPHOSPHORAMIDITE
- DIMETHYLPHOSPHORAMIDOUS DICHLORIDE
- AURORA KA-1672
- DICHLORO N,N-DIETHYLPHOSPHORAMIDITE
- N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE