TP0427736
TP0427736 Basic information
- Product Name:
- TP0427736
- Synonyms:
-
- TP0427736
- TP0427736 HCl
- TP427736
- TP-427736
- Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-
- CAS:
- 864374-00-5
- MF:
- C14H10N4S2
- MW:
- 298.39
- Mol File:
- 864374-00-5.mol
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TP0427736 Chemical Properties
- Boiling point:
- 634.7±65.0 °C(Predicted)
- Density
- 1.439±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble
- pka
- 9.70±0.10(Predicted)
- Water Solubility
- Water: Insoluble
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TP0427736 Usage And Synthesis
Biological Activity
TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM.
in vitro
TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2.
in vivo
TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen.
target
| Target | Value |
| ALK5 (Cell-free assay) | 2.72 nM |
TP0427736Supplier
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Guangzhou Tomums Life Science Co., Ltd.
- Tel
- 020-31155029 18902330969
- sales@tomums.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
InvivoChem
- Tel
- +1-708-310-1919 +1-13798911105
- sales@invivochem.cn