TC-2153 Chemical Properties

storage temp. 

-20°C

solubility 

DMSO: 5mg/mL, clear

form 

powder

color 

white to beige

TC-2153 Usage And Synthesis

Biochem/physiol Actions

TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.

TC-2153(1381769-23-8)Related Product Information

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