(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties

Melting point:

156-159 °C (lit.)

alpha 

-41 º (c=% in ethanol)

Boiling point:

363.6±35.0 °C(Predicted)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Slightly soluble in water

pka

13.62±0.20(Predicted)

form 

Solid

color 

White to off-white

optical activity

[α]23/D 43°, c = 1 in ethanol

BRN 

1524192

InChIKey

IOGISYQVOGVIEU-VKHMYHEASA-N

CAS DataBase Reference

68108-18-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

22-24/25-36-26

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

(S)-4-Hydroxy-2-pyrrolidinone Usage And Synthesis

Chemical Properties

White crystal

Uses

(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

• Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
• Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

Uses

The (S)-enantiomer intermediate in the preparation of Oxiracetam

General Description

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

(S)-4-Hydroxy-2-pyrrolidinone(68108-18-9)Related Product Information

• N-Vinyl-2-pyrrolidone
• CHLOROPHOSPHONAZO III
• Polyvinylpyrrolidone
• 2-Pyrrolidinone
• N-Methyl-2-pyrrolidone
• Povidone iodine
• 4-hydroxypyrrolidin-2-one
• OxiracetaM Related CoMpound 2
• Oxiracetam Related Compound 7
• Oxiracetam
• 2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide
• Oxiracetam Related Compound 8
• methyl 4-hydroxy-2-oxopyrrolidine-1-acetate
• 2-[(carbamoylmethyl)amino]acetamide
• Oxiracetam Related Compound 5
• 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid
• (4S)-4-hydroxy-2-oxo-1-Pyrrolidineacetic acid Methyl ester
• ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate