AH 11110 HYDROCHLORIDE Chemical Properties

storage temp. 

−20°C

solubility 

H₂O: ~2.5 mg/mL, soluble

form 

solid

color 

slightly yellow

Water Solubility 

Soluble to 25 mM in water

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

AH 11110 HYDROCHLORIDE Usage And Synthesis

Uses

AH 11110 Hydrochloride is an α1B-adrenoceptor selective drug. AH 11110 Hydrochloride has been shown to interact with α1-adrenoceptors as well as α2-adrenoceptors.

Biological Activity

A subtype-selective ligand for the α 1B -adrenoceptor. The pK i values for binding to rat fibroblast cell membranes expressing α 1B (hamster), α 1A (bovine) and α 1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α 1 subtypes and α 2 receptors in smooth muscle preparations.

References

[1]. erami c, zhang h, ho jg, et al. alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. am j physiol heart circ physiol, 2002, 283(4): h1577-1587.
[2]. eltze m, könig h, ullrich b, et al. failure of ah11110a to functionally discriminate between alpha(1)-adrenoceptor subtypes a, b and d or between alpha(1)- and alpha(2)-adrenoceptors. eur j pharmacol, 2001, 415(2-3): 265-276.

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