HS-10296
HS-10296 Basic information
- Product Name:
- HS-10296
- Synonyms:
-
- HS-10296
- N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide
- HS-10296;HS 10296;HS10296;1899921-05-1
- HS 10296;HS10296
- Almonertinib (HS-10296)
- Almonertinib
- 2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
- N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
- CAS:
- 1899921-05-1
- MF:
- C30H35N7O2
- MW:
- 525.66
- Mol File:
- 1899921-05-1.mol
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HS-10296 Chemical Properties
- Density
- 1.24±0.1 g/cm3(Predicted)
- solubility
- DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM) - pka
- 12.68±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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HS-10296 Usage And Synthesis
Uses
Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.
Mechanism of action
Almonertinib inhibits EGFR tyrosine kinase targeting EGFR-sensitizing and T790M resistance mutations.
HS-10296Supplier
CAREBIO PHARMA Gold
- Tel
- 18501057619 18501057619
- jackyfan@rebornpharma.com
Wuhan Jingkangen Biomedical Technology Co., Ltd Gold
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
Suzhou Chenrui Biotechnology Co. LTD Gold
- Tel
- 17625585511
- 1580084073@qq.com
ChemShuttle, Inc.
- Tel
- 0510-83588313-811 18800520310;
- sales@chemshuttle.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com