HS-10296

Product Name: HS-10296
CAS No.: 1899921-05-1
Chemical Name: HS-10296
Synonyms: HS-10296;Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-;inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
CBNumber: CB14808621
Molecular Formula: C30H35N7O2
Formula Weight: 525.66
MOL File: 1899921-05-1.mol

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HS-10296 Property

Density: 1.24±0.1 g/cm3(Predicted)
solubility: DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM)
pka: 12.68±0.70(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 25mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573138
Product name: HS-10296
Purity: >98%
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

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HS-10296 Chemical Properties,Usage,Production

Uses

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

Mechanism of action

Almonertinib inhibits EGFR tyrosine kinase targeting EGFR-sensitizing and T790M resistance mutations.

HS-10296 Preparation Products And Raw materials

Raw materials

Preparation Products

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HS-10296 Suppliers

China 57 United States 4 USA 1 Global 62

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5821
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CAREBIO PHARMA

Tel: 18501057619
Email: 771737847@qq.com
Country: China
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Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 667
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ChemShuttle, Inc.

Tel: 0510-83588313-802 18800520310;
Email: sales@chemshuttle.com
Country: China
ProdList: 3002
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7892
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
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1899921-05-1, HS-10296Related Search:

HS-10296

N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide

HS-10296;HS 10296;HS10296;1899921-05-1

HS 10296;HS10296

Almonertinib (HS-10296)

Almonertinib

2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-

N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

2H6]-Almonertinib

inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC

1899921-05-1

C30H35N7O2