H-GLY-PRO-GLY-NH2 HCL Chemical Properties

Boiling point:

618.0±55.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

-15°C

pka

14.27±0.20(Predicted)

Sequence

H-Gly-Pro-Gly-NH2 · HCl

H-GLY-PRO-GLY-NH2 HCL Usage And Synthesis

Uses

H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 μM and 30 μM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3].

IC 50

HIV (IIIB): 35 μM (EC₅₀); HIV-2 (ROD): 30 μM (EC₅₀)

References

[1] H?glund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605. DOI:10.1128/AAC.46.11.3597-3605.2002
[2] Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124.
[3] Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59. DOI:10.1016/j.biocel.2004.02.017

H-GLY-PRO-GLY-NH2 HCL(141497-12-3)Related Product Information

• Antide
• Z-GLY-PRO-ARG-AMC HCL
• H-LEU-ARG-PRO-GLY-NH2 2HCL
• BOC-VAL-PRO-ARG-AMC HCL
• spantide II
• N-P-TOSYL-GLY-PRO-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• BOC-ASP(OBZL)-PRO-ARG-AMC HCL
• ANTHO-RPAMIDE I
• SAR-PRO-ARG P-NITROANILIDE DIHYDROCHLORIDE
• ALPHA-MSH (11-13)
• TOS-GLY-PRO-LYS-AMC ACOH
• AC-(PCL)DPHE-(PCL)DPHE-DTRP-SER-TYR-DARG-LEU-ARG-PRO-DALA-NH2
• BOC-ALA-GLY-PRO-ARG-7-AMINO-4-METHYLCOUMARIN
• BETA-CASOMORPHIN[1-4] AMIDE HYDROCHLORIDE
• ARG-PRO-LYS-PRO-GLN-GLN-P-CHLORO-PHE-P-CHLORO-PHE-GLY-LEU-MET-NH2
• (P-CHLORO-PHE5,8)-BRADYKININ
• H-GLY-PRO-LEU-BETA-NA HCL
• (BOC-LYS9)-NEUROTENSIN (9-13)-METHYL ESTER