4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Chemical Properties

Melting point:

224-226 °C

Boiling point:

536.1±50.0 °C(Predicted)

Density 

1.575±0.06 g/cm3(Predicted)

storage temp. 

−20°C

pka

12.35±0.70(Predicted)

form 

Solid

color 

Off-white to light yellow

Safety Information

WGK Germany 

3

MSDS

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4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Usage And Synthesis

Uses

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

Definition

ChEBI: A member of the class of aminopyrimidines that is 4,6-diaminopyrimidine bearing an additional formamido substituent at position 5. A DNA lesion formed when DNA exposed to ionising radiation.

in vivo

IC 50

Human Endogenous Metabolite

References

[1] Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. DOI:10.1046/j.1471-4159.1998.71052034.x
[2] Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. DOI:10.1515/znc-1999-3-414
[3] Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. DOI:10.1046/j.1471-4159.1998.71052034.x

4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE(5122-36-1)Related Product Information

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