Amino-PEG5-t-butyl acetate
Amino-PEG5-t-butyl acetate Basic information
- Product Name:
- Amino-PEG5-t-butyl acetate
- Synonyms:
-
- Amino-PEG5-t-butyl acetate
- 3,6,9,12,15-Pentaoxaheptadecanoic acid,17-amino-, 1,1-dimethylethyl ester
- H2N-PEG5-CH2COOtBu
- NH2-PEG5-C1-Boc
- NH2-PEG5-CH2COOtBu
- tert-butyl 17-amino-3,6,9,12,15-pentaoxaheptadecanoate
- H2N-PEG5-CH2COOtBu/3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-amino-, 1,1-dimethylethyl ester
- CAS:
- 2231845-67-1
- MF:
- C16H33NO7
- MW:
- 351.44
- Mol File:
- 2231845-67-1.mol
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Amino-PEG5-t-butyl acetate Usage And Synthesis
Biological Activity
NH2-PEG5-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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