CEVIMELINE, HYDROCHLORIDE SALT Chemical Properties

Melting point:

195-197°C

Boiling point:

308.5±42.0 °C(Predicted)

Density 

1.19

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Soluble in DMSO

form 

Powder

pka

9.51±0.40(Predicted)

CAS DataBase Reference

107233-08-9

Safety Information

Hazardous Substances Data

107233-08-9(Hazardous Substances Data)

CEVIMELINE, HYDROCHLORIDE SALT Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

A muscarinic M1 and M3 receptor agonist. Sialagogue

Biological Activity

cevimeline is a muscarinic receptor agonist especially on the m1 and m3 receptors. [1]cevimeline has been approved for use against symptoms of dry mouth by activating the m3 receptors of the parasympathetic nervous system. cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. cevimeline increased the intracellular ca+ level in parotid gland acinar cells over 1 μm and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. cevimeline has a longer duration of salivation[3]. cevimeline plays a part in alzheimer’s disease. cevimeline decreased aβ (1–40) level in the cerebrospinal fluid (csf) at 1 mg/kg without changing α-apps in rabbit and significantly decreased csf aβ in ad patients.[4]

References

1. f. b. vivino, i. al-hashimi, z. khan, f. g. leveque, p. l. salisbury, 3rd, t. k. tran-johnson, c. c. muscoplat, m. trivedi, b. goldlust and s. c. gallagher, arch intern med 1999, 159, 174-181. 2. m. ono, e. takamura, k. shinozaki, t. tsumura, t. hamano, y. yagi and k. tsubota, am j ophthalmol 2004, 138, 6-17. 3. k. ono, t. inagaki, t. iida, r. hosokawa and k. inenaga, j med invest 2009, 56 suppl, 375. 4. a. fisher, z. pittel, r. haring, n. bar-ner, m. kliger-spatz, n. natan, i. egozi, h. sonego, i. marcovitch and r. brandeis, j mol neurosci 2003, 20, 349-356.

CEVIMELINE, HYDROCHLORIDE SALT(107233-08-9)Related Product Information

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• CEVIMELINE, HYDROCHLORIDE SALT
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• cevimeline