Basic information Safety Supplier Related

CEVIMELINE, HYDROCHLORIDE SALT

Basic information Safety Supplier Related

CEVIMELINE, HYDROCHLORIDE SALT Basic information

Product Name:
CEVIMELINE, HYDROCHLORIDE SALT
Synonyms:
  • CevimelineHClSalt
  • (+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3quinuclidine
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-rel-
  • Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, cis-
  • 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine
  • AF-102B
  • Evoxac
  • SNI-2011
CAS:
107233-08-9
MF:
C10H17NOS
MW:
199.31
Product Categories:
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
Mol File:
107233-08-9.mol
More
Less

CEVIMELINE, HYDROCHLORIDE SALT Chemical Properties

Melting point:
195-197°C
Boiling point:
308.5±42.0 °C(Predicted)
Density 
1.19
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
9.51±0.40(Predicted)
CAS DataBase Reference
107233-08-9
More
Less

Safety Information

Hazardous Substances Data
107233-08-9(Hazardous Substances Data)
More
Less

CEVIMELINE, HYDROCHLORIDE SALT Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

A muscarinic M1 and M3 receptor agonist. Sialagogue

Biological Activity

cevimeline is a muscarinic receptor agonist especially on the m1 and m3 receptors. [1]cevimeline has been approved for use against symptoms of dry mouth by activating the m3 receptors of the parasympathetic nervous system. cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. cevimeline increased the intracellular ca+ level in parotid gland acinar cells over 1 μm and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. cevimeline has a longer duration of salivation[3]. cevimeline plays a part in alzheimer’s disease. cevimeline decreased aβ (1–40) level in the cerebrospinal fluid (csf) at 1 mg/kg without changing α-apps in rabbit and significantly decreased csf aβ in ad patients.[4]

References

1. f. b. vivino, i. al-hashimi, z. khan, f. g. leveque, p. l. salisbury, 3rd, t. k. tran-johnson, c. c. muscoplat, m. trivedi, b. goldlust and s. c. gallagher, arch intern med 1999, 159, 174-181. 2. m. ono, e. takamura, k. shinozaki, t. tsumura, t. hamano, y. yagi and k. tsubota, am j ophthalmol 2004, 138, 6-17. 3. k. ono, t. inagaki, t. iida, r. hosokawa and k. inenaga, j med invest 2009, 56 suppl, 375. 4. a. fisher, z. pittel, r. haring, n. bar-ner, m. kliger-spatz, n. natan, i. egozi, h. sonego, i. marcovitch and r. brandeis, j mol neurosci 2003, 20, 349-356.

CEVIMELINE, HYDROCHLORIDE SALTSupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Email
sales@capotchem.com
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com