3-METHYLOXINDOLE 96 Chemical Properties

Melting point:

117-121 °C(lit.)

Boiling point:

279.3±29.0 °C(Predicted)

Density 

1.123±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

form 

Solid

pka

14.81±0.40(Predicted)

color 

Light Beige to Beige

Water Solubility 

Insoluble in water.

CAS DataBase Reference

1504-06-9

Safety Information

WGK Germany 

3

HS Code 

2933790090

3-METHYLOXINDOLE 96 Usage And Synthesis

Uses

• ;Reactant for enantioselective α-amination reactions1• ;Reactant for aldol reaction with glyoxal derivatives2• ;Reactant for amine thiourea catalyzed conjugate addition to α,β-unsaturated aldehydes3• ;Reactant for O-acetylation reactions4• ;Reactant for preparation of a disubstituted oxoindole by using rhodium-catalyzed cyclopropanation/ring-opening reactions5

Uses

A versatile reactant. As 3-Methylindole metabolite. Reactant for enantioselective α-amination reactions, Reactant for aldol reaction with glyoxal derivatives, Reactant for amine thiourea catalyzed conjugate addition to α,β-unsaturated aldehydes, Reactant for O-acetylation reactions, Reactant for preparation of a disubstituted oxoindole by using rhodium-catalyzed cyclopropanation/ring-opening reactions.

Definition

ChEBI: 3-methyloxindole is a member of the class of oxindoles that is oxindole (1,3-dihydro-2H-indol-2-one) in which one of the hydrogens at position 3 has been replaced by a methyl group. It is a member of oxindoles and a methylindole.

General Description

3-Methyl-2-oxindole (MOI) is a 3-substituted-2-oxindole. It is reported to be formed during the oxidation of indole-3-acetic acid in the presence of Fe^II under aerobic conditions. MOI undergoes asymmetric anti-Mannich-type reaction with N-tosyl aryl aldimines in the presence of alkaloid cinchona derivatives to form anti-3,3-disubsituted 2-oxindole derivatives. It also undergoes asymmetric hydroxyamination with nitrosoarenes to form N-nitroso aldol products.

3-METHYLOXINDOLE 96(1504-06-9)Related Product Information

• 3-Methylthiopropanol
• 3-(Methylthio)butanal
• 3-(Methylthio)propionaldehyde
• 3-Picoline
• oxyphenisatine di(acetate)
• 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
• GELSEMINE
• Amedalin
• ETHYL 3-HYDROXY-4,6-DIMETHOXY-2-OXOINDOLINE-3-CARBOXYLATE
• 3-PHENYL-OXINDOLE
• 3-hydroxy-3-acetonyl-2-oxindole
• 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
• 1H-Indole-3-acetonitrile, 2,3-dihydro-2-oxo-
• 3-HYDROXY-3-PHENYLOXINDOLE
• 3-(2-AMINO-ETHYL)-1,3-DIHYDRO-INDOL-2-ONE
• 3-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1,3-DIHYDRO-2H-INDOL-2-ONE
• 3-METHOXY-1-(4-METHOXYPHENYL)-5-((4-METHYLPHENYL)CARBONYL)SPIRO[AZETIDINE-4,3'-INDOLINE]-2,6-DIONE
• BUTTPARK 58\40-88