CAMBENDAZOL Chemical Properties

Melting point:

212-214℃ (ethyl acetate hexane )

Density 

1.2909 (rough estimate)

refractive index 

1.6440 (estimate)

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml

pka

9.99±0.10(Predicted)

form 

Solid

color 

Light yellow to brown

BRN 

563292

Major Application

forensics and toxicology
pharmaceutical (small molecule)

InChI

1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)

InChIKey

QZWHWHNCPFEXLL-UHFFFAOYSA-N

SMILES

CC(C)OC(=O)Nc1ccc2[nH]c(nc2c1)-c3cscn3

Safety Information

Hazard Codes 

Xn

Risk Statements 

63

Safety Statements 

36/37

WGK Germany 

3

RTECS 

DD6538000

Storage Class

11 - Combustible Solids

Hazard Classifications

Repr. 2

CAMBENDAZOL Usage And Synthesis

Description

Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle. It inhibits polymerization of microtubules isolated from bovine brain with an IC₅₀ value of 64.2 μM. Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.

Uses

Anthelmintic.

brand name

Camdan (Merck);.

References

[1] GROVE D I. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice.[J]. The American journal of tropical medicine and hygiene, 1982: 469-476. DOI: 10.4269/ajtmh.1982.31.469
[2] PAUL A. FRIEDMAN  Edward G P. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin[J]. Biochimica et biophysica acta. General subjects, 1978, 544 3: Pages 605-614. DOI: 10.1016/0304-4165(78)90334-3
[3] S A BICALHO  Q P  O J Le?o. Cambendazole in the treatment of human strongyloidiasis.[J]. American Journal of Tropical Medicine and Hygiene, 1983, 32 5: 1181-1183. DOI: 10.4269/ajtmh.1983.32.1181
[4] ROSSE* G. Compositions and Methods for the Treatment of Mitochondrial Diseases[J]. ACS Medicinal Chemistry Letters, 2012, 3 12: 954. DOI: 10.1021/ml3002924

CAMBENDAZOL(26097-80-3)Related Product Information

• Diclazuril
• 4-(1H-IMIDAZOL-2-YL)-THIAZOLE
• CAMBENDAZOL
• Thiabendazole