4-DEOXYPYRIDOXINE 5-PHOSPHATE Chemical Properties

storage temp. 

Store at -20°C

solubility 

Water: soluble

form 

A crystalline solid

color 

White to off-white

Water Solubility 

Water: soluble

4-DEOXYPYRIDOXINE 5-PHOSPHATE Usage And Synthesis

Uses

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].

References

[1] Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. DOI:10.1007/s11745-016-4187-0
[2] M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9. DOI:10.1111/1523-1747.ep12543346
[3] D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32. DOI:10.1111/j.1471-4159.1990.tb04166.x

4-DEOXYPYRIDOXINE 5-PHOSPHATE(883-84-1)Related Product Information

• 4-deoxypyridoxine
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• PPADS TETRASODIUM SALT
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• PYRIDOXAMINE-5'-PHOSPHATE
• PYRIDOXAL 5-PHOSPHATE, [14C]
• Pyridoxal 5'-phosphate monohydrate
• MRS 2211
• 4-DEOXYPYRIDOXINE 5-PHOSPHATE