HSF, 1 antibody Usage And Synthesis

Source

Rabbit

Applications

HSF1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:1,000~ 2,000. Recommended starting dilution is 1:1,000.

Reactivity

Human;Mouse;Rat;Monkey

Immunogen

Anti-human HSF1 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HSF1 amino acids 1-529 purified from E. coli.

Background

The transcription of heat-shock genes is rapidly induced after temperature stress in response to environmental changes, and it is also involved in oogenesis, spermatogenesis, and placental development. Hsp90, is a major repressor of HSF1 gene. HSF1 is known for its participation in heat shock response. HSF1 protein regulates the transcription of hundreds of targets, such as genes involved in protein folding, detoxification, energy generation, carbohydrate metabolism, and cell wall organization. HSF1 binds to MTA1 in vitro & in breast carcinoma. Suppression of estrogen-dependent transcription may contribute to role of HSF1 in cancer. Human cancer lines of diverse origins express higher dependence on HSF1 function to maintain proliferation and survival than their non-transformed counterparts. HSF1 induces anticoagulation and relaxation factors in vascular endothelial cells and could therefore be used to treat cardiovascular disease. HSF1 is directly involved in the regulation of HO1 havi

References

[1] Morimoto, R.I. (1998) Genes Dev 12, 3788-96.
[2] Mercier, P.A. et al. (1999) J Cell Sci 112 ( Pt 16), 2765-74.
[3] Kim, S.A. et al. (2005) J Biol Chem 280, 12653-7.
[4] Holmberg, C.I. et al. (2001) EMBO J 20, 3800-10.
[5] Chu, B. et al. (1996) J Biol Chem 271, 30847-57.
[6] Wang, X. et al. (2003) Mol Cell Biol 23, 6013-6.
[7] Satyal, S.H. et al. (1998) Genes Dev 12, 1962-74.

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