IRS2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Insulin Receptor Substrate 2 is one of the major substrates of the insulin receptor kinase. In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades. IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults.

References

[1] Sun, X.J. et al. (1991) Nature 352, 73-77.
[2] White, M.F. (2002) Am. J. Physiol. Endocrinol. Metab. 283, E413-E422.
[3] Withers, D.J. et al. (1998) Nature 391, 900-904.

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