Ki-67 (D3B5) Rabbit mAb Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Ki-67, named after the location where it was discovered, is a nuclear nonhistone protein that is universally expressed among proliferating cells and absent in quiescent cells. Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival. Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases.

References

[1] Gerdes, J. et al. (1983) Int J Cancer 31, 13-20.
[2] Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62.
[3] Jones, R.L. et al. (2009) Breast Cancer Res Treat 116, 53-68.
[4] Yerushalmi, R. et al. (2010) Lancet Oncol 11, 174-83.

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