NAPHTHOFLUORESCEIN
NAPHTHOFLUORESCEIN Basic information
- Product Name:
- NAPHTHOFLUORESCEIN
- Synonyms:
-
- NAPHTHOFLUORESCEIN
- NAPHTHOFLUORESCEIN, FOR FLUORESCENCE
- NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%
- Naphthafluorescein
- Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
- CAS:
- 61419-02-1
- MF:
- C28H16O5
- MW:
- 432.42
- EINECS:
- 634-716-5
- Mol File:
- 61419-02-1.mol
NAPHTHOFLUORESCEIN Chemical Properties
- Melting point:
- 189 °C (dec.)(lit.)
- Boiling point:
- 755.5±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble
- form
- A crystalline solid
- pka
- 8.82±0.20(Predicted)
- color
- Purple to purplish red
- BRN
- 61335
- InChIKey
- IXQIUDNVFVTQLJ-UHFFFAOYSA-N
- EPA Substance Registry System
- Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1)
MSDS
- Language:English Provider:SigmaAldrich
NAPHTHOFLUORESCEIN Usage And Synthesis
Uses
Naphthofluorescein is a furin inhibitor.
Uses
Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.
Definition
ChEBI: Naphthofluorescein is a member of xanthenes.
in vivo
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner[1].
| Animal Model: | Male C57BL/6J mice (8 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney, or caused cause severe adverse effects for at least 2 weeks in mice. |
| Animal Model: | Female C57BL/6J mice (E0771) and BALB/c nude mice (HT1080, MDA-MB-231, and AsPC-1) (6 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Strikingly suppressed the tumour growth of subcutaneously injected E0771 cells and significantly attenuated tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein did not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells. |
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