BENZYL CIS-4-AMINOCYCLOHEXYLCARBAMATE Chemical Properties

Boiling point:

409.5±44.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

pka

12.23±0.40(Predicted)

Safety Information

HS Code 

2924297099

BENZYL CIS-4-AMINOCYCLOHEXYLCARBAMATE Usage And Synthesis

Synthesis

Step B: Synthesis of cis-(4-amino-cyclohexyl)-carbamic acid benzyl ester. To a solution of cis-(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid benzyl ester (6.2 g, 0.018 mol) in dichloromethane (40 mL) was added trifluoroacetic acid (2.7 mL, 0.36 mol). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the excess solvent was removed by rotary evaporation and the resulting oil was dissolved in dichloromethane (30 mL). The organic layer was extracted with dilute aqueous sodium hydroxide/aqueous sodium bicarbonate solution (30 mL). The aqueous layer was back-extracted twice with dichloromethane, and the organic layers were combined, dried over anhydrous magnesium sulfate, and concentrated to give cis-(4-amino-cyclohexyl)-carbamic acid benzyl ester (4.3 g, 97%) as a colorless oil. The product was used directly in the next reaction without further purification.ESI MS m/z 249.2 [M + H]+.

References

[1] Patent: EP1464335, 2004, A2. Location in patent: Page/Page column 293

BENZYL CIS-4-AMINOCYCLOHEXYLCARBAMATE(149423-70-1)Related Product Information

• Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
• BENZYL CIS-4-AMINOCYCLOHEXYLCARBAMATE
• trans-1,4-Diaminocyclohexane