ANTI-IQGAP1 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Storage Class

10 - Combustible liquids

ANTI-IQGAP1 Usage And Synthesis

Uses

Anti-IQGAP1 antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunohistochemistry

Biological Activity

The gene IQGAP1 (IQ motif containing GTPase activating protein 1) encodes a key effector of Rac1 and Cdc42, Rho-family of small GTPases th at regulate E-cadherin–mediated cell-cell adhesion. It functions in the modulation of actin cytoskeleton along with Rac1 and Cdc42. The encoded protein modulates cell–cell adhesion through E-cadherin and β-catenin. It participates in the regulation of mitogen activated protein kinase pathway th at is involved in cell proliferation and differentiation. IQGAP1 is a scaffold protein th at bridges the proteins involved in signaling cascades and participates in several cellular processes. It binds to and stabilizes microtubules via CLIP-170, a microtubule-binding protein, near the cell cortex. This results in the formation and maintenance of polarized cell morphology and directional cell migration.