(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Basic information
- Product Name:
- (PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
- Synonyms:
-
- LPFFD
- BETA-SHEET BREAKER PEPTIDE IA-BETA5P
- BETA-SHEET BREAKER PEPTIDE IA-BETA5
- (PRO18,ASP21)AMYLOID BETA PROTEIN*FRAGMENT (17-21)
- [pro18, asp21]-amyloid β protein fragment 17-21 trifluoroacetate salt
- LEU-PRO-PHE-PHE-ASP
- H-LEU-PRO-PHE-PHE-ASP-OH
- IA-BETA5
- CAS:
- 182912-74-9
- MF:
- C33H43N5O8
- MW:
- 637.72
- Product Categories:
-
- peptide
- Alzheimers and Neurodegenerative Disease Research
- Amyloid beta Protein Fragments
- Amyloid β Protein FragmentsNeuropeptides
- Neurodegenerative Disease Peptides
- β Amyloid Peptides
- Mol File:
- 182912-74-9.mol
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Chemical Properties
- Boiling point:
- 980.0±65.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic
- form
- solid
- pka
- 2.88±0.10(Predicted)
- color
- White to off-white
- Sequence
- Leu-Pro-Phe-Phe-Asp
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) Usage And Synthesis
Uses
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
in vivo
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat; Intra-amygdala injection; 7 days) coinjected with Aβ1-42 (5 nmol) into in the rat amygdala, blocks Aβ1-42 neurotoxicity in tissue culture, and amyloid fibril formation in the rat model[1].
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat, 200 nmol/rat; Intra-amygdaloid injection; 7 days) followed by Aβ1-42 (5 nmol), induces disassembly of pre-existing Aβ fibrils in vivo, and leads to a reversal or prevention of Aβ-induced histopathological changes in rat model[2].
References
[1] Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med. 1998 Jul;4(7):822-6. DOI:10.1038/nm0798-822
[2] Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. DOI:10.1093/jnen/59.1.11
[3] Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7. DOI:10.1021/acs.orglett.5b02057
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)Supplier
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(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)(182912-74-9)Related Product Information
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- ACETYL-(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) AMIDE
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