2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Basic information
- Product Name:
- 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
- Synonyms:
-
- GSTO1-IN-1
- 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
- GSTO1 inhibitor 1
- Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-
- 2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide
- 2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide
- GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1
- CAS:
- 568544-03-6
- MF:
- C10H12Cl2N2O3S
- MW:
- 311.18
- Mol File:
- Mol File
More
Less
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
More
Less
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Usage And Synthesis
Biological Activity
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM.
in vitro
GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations.
target
IC50: 31 nM (GSTO1)
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDESupplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Shenzhen Regent Biochemical Technology Co., Ltd.
- Tel
- 0755-0755-85201366 18938635012
- sales@regentsciences.com
Twochem Co.Ltd.
- Tel
- 021-58111628 15800915896
Jiangsu aikang biomedical research and development co., LTD
- Tel
- 025-66110311 13155353615
- qzhang@aikonchem.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
- Tel
- 18081075745
- chemflowtech@sina.com