CHEMPACIFIC 38154 Chemical Properties

Melting point:

199-202°

Boiling point:

349.5±37.0 °C(Predicted)

Density 

1.929±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Solid

pka

-1.73±0.50(Predicted)

color 

Yellow to green

CAS DataBase Reference

84487-04-7

Safety Information

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

2933399990

CHEMPACIFIC 38154 Usage And Synthesis

Synthesis

2,6-Dichloro-5-nitropyridine (20.0 g, 95.3 mmol) was used as a raw material, which was dissolved in ethanol (300 mL) and ammonia (60 mL) was added slowly. The reaction mixture was stirred at room temperature for 10 hours. After the reaction was completed, the precipitate was collected by filtration, washed with ethanol and dried under vacuum to obtain 6-amino-2-chloro-5-nitropyridine (13.8 g, 83% yield). The resulting 6-amino-2-chloro-5-nitropyridine was suspended in 30% hydrogen bromide in acetic acid solution (130 mL). The suspension was heated to 100 °C and stirred for 26 hours. After completion of the reaction, it was cooled to room temperature and concentrated in vacuum to remove the solvent. The residue was extracted with ethyl acetate and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and saturated brine, dried over anhydrous magnesium sulfate and concentrated in vacuum. The final product 6-bromo-3-nitropyridin-2-amine was purified by recrystallization from ethyl acetate to give white crystals (14.93 g, 86% yield).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5702 - 5713
[2] Patent: WO2004/2986, 2004, A2. Location in patent: Page 127-128
[3] Patent: US6348474, 2002, B1. Location in patent: Page column 44,45

CHEMPACIFIC 38154(84487-04-7)Related Product Information

• N1-(1-BROMO-4-NITRO-3-ISOQUINOLYL)BENZAMIDE
• 6-BROMOPYRIDINE-2,3-DIAMINE
• 2-Bromo-5-nitropyridine
• CHEMPACIFIC 38154