7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Basic information
- Product Name:
- 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
- Synonyms:
-
- 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
- FR 167653
- FR 167653 sulfate
- CAS:
- 158876-66-5
- MF:
- C24H20FN5O6S
- MW:
- 525.51
- Mol File:
- 158876-66-5.mol
7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Light yellow to yellow
7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Usage And Synthesis
Uses
FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].
in vivo
FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].
| Animal Model: | Inbred male Balbuc mice (aged 8 weeks)[1] |
| Dosage: | 32 kg/mg |
| Administration: | Subcutaneous injection; 24-48 hours |
| Result: | The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla. |
References
[1] Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. DOI:10.1093/ndt/17.3.399
[2] Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. DOI:10.1097/01.asn.0000037402.83851.5f
[3] Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74. DOI:10.1016/s1053-2498(01)00243-1
7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATESupplier
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7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE(158876-66-5)Related Product Information
- 3-(4-Fluorophenyl)-1H-pyrazole
- 4-(1H-PYRAZOL-4-YL)PYRIDINE
- 2-(3-METHYL-PYRAZOL-1-YL)-ETHYLAMINE
- 4-METHYL-5-PHENYL-2H-PYRAZOL-3-YLAMINE
- 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
- N-ETHYL-2-(1H-PYRAZOL-1-YL)ETHANAMINE
- CHEMBRDG-BB 4010204
- 4-(4-Pyridinyl)-1H-pyrazol-3-aMine
- 4-Methylpyrazolesulfate
- 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine
- 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE
- 4-Methylpyridine
- Phenelzine Sulfate