5,7-DIMETHOXY-INDAN-1-ONE Chemical Properties

Melting point:

99-100 °C

Boiling point:

352.6±42.0 °C(Predicted)

Density 

1.34 g/cm3

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to light yellow Solid

5,7-DIMETHOXY-INDAN-1-ONE Usage And Synthesis

Uses

5,7-Dimethoxyindan-1-one acts as a reagent for the preparation and antitumor activities of phenyl- and benzothiazolylisoquinolinedienes.

Uses

5,7-Dimethoxyindan-1-one acts as a reagent for the preparation and antitumor activities of phenyl- and benzothiazolylisoquinolinedienes.

Synthesis

The general procedure for the synthesis of 5,7-dimethoxyindanone from 3,5-dimethoxyphenylpropionic acid was as follows: 3-(3,5-dimethoxyphenyl)propionic acid (2 g x 5) was dissolved in methanesulfonic acid (10 ml x 5) in a microwave treated vial (20 ml x 5). The reaction mixture was heated at 90°C for 10 min under microwave radiation. After completion of the reaction, the mixture was slowly poured into ice (250 g) and neutralized to pH 8-9 with 2 M NaOH solution, followed by extraction with EtOAc. The organic layers were combined and the target product 5,7-dimethoxyindanone (8.8 g, 96.2% yield) was obtained after concentration. The product was analyzed by LC-MS and showed m/e 193 (MH+).

References

[1] Chemistry - An Asian Journal, 2015, vol. 10, # 4, p. 1050 - 1064
[2] Tetrahedron, 2007, vol. 63, # 2, p. 389 - 395
[3] Patent: WO2007/71348, 2007, A1. Location in patent: Page/Page column 87
[4] ChemMedChem, 2018, vol. 13, # 18, p. 1949 - 1956
[5] Tetrahedron Letters, 1980, vol. 21, # 37, p. 3603 - 3606

5,7-DIMETHOXY-INDAN-1-ONE(880-87-5)Related Product Information

• 3-Chloroperoxybenzoic acid
• 5-Chloro-1-indanone
• 9(10H)-ACRIDONE
• Indan
• 4,5-DIMETHOXY-INDAN-1-ONE
• 5,6-DIMETHOXY-INDAN-1-ONE
• 2-ALLYL-5,6-DIMETHOXY-INDAN-1-ONE
• 2-[1-(1-BENZYL-PIPERIDIN-4-YL)-METH-(E)-YLIDENE]-5,6-DIMETHOXY-INDAN-1-ONE
• 4,7-DIMETHOXY-INDAN-1-ONE
• 5,7-DIMETHOXY-3,3-DIMETHYL-INDAN-1-ONE
• 5,7-DIMETHOXY-2,3-DIMETHYL-INDAN-1-ONE
• 5-Methoxy-1-indanone
• 5,7-DIMETHOXY-2-METHYL-INDAN-1-ONE
• 5,7-DIMETHOXY-INDAN-1-ONE